P. Singh

A large-scale crowd-sourced annotated acoustic dataset of Indian fauna

The paper creates a crowd-sourced acoustic dataset of Indian fauna to support biodiversity monitoring and deep learning applications in conservation.

Interfacial vortex recapture enhances thrust in tiny water skaters

This study investigates interfacial vortex recapture in Microvelia americana, showing how it enhances thrust through vortex re-energization and tripod gait mechanics.

Bolstering Wheat's Immunity: BABA-Mediated Defense Priming Against Bipolaris sorokiniana Amid Competition

This study shows BABA priming improves wheat resistance to Bipolaris sorokiniana under competition, maintaining growth and yield better than non-primed plants.

ATTRv-V30M Type A amyloid fibrils from the heart and nerves exhibit structural homogeneity.

This study determines the structure of ATTRv-V30M amyloid fibrils from cardiac and nerve tissues using cryo-EM, finding structural homogeneity across tissues when transthyretin originates from the liver.

Rapid, high-resolution, non-destructive assessments of metabolic and morphological homogeneity uniquely identify high-grade cervical precancerous lesions

This paper uses two-photon microscopy to detect high-grade cervical precancerous lesions with high sensitivity and specificity by analyzing metabolic and morphological features.

Olive phenolic compounds, potent tankyrase 1 inhibitor exhibit anti colon cancer effects by blocking Wnt/β-catenin pathway

This study identifies olive polyphenols as tankyrase 1 inhibitors that suppress the Wnt/β-catenin pathway, reducing colon cancer cell viability and target gene expression.

Genetic architecture underlying response to the fungal pathogen Dothistroma septosporum in lodgepole pine, jack pine, and their hybrids

This study identifies genetic factors underlying resistance to Dothistroma septosporum in lodgepole pine, jack pine, and their hybrids using genome-wide association analysis.

DAB-APT: a Fluorescence-Based Assay for Determining Aminopropyl Transferase Activity and Inhibition

The paper develops a fluorescence-based assay, DAB-APT, to measure aminopropyl transferase activity and inhibition, validated with enzymes from S. cerevisiae and P. falciparum.

Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation

The paper shows that nuclear compression-induced DNA damage drives mESC differentiation via ATR-dependent Lamin A/C regulation.

Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis

The paper uses cryo-EM to show that cardiac ATTRwt amyloid fibrils from four patients are structurally identical, supporting their consistent clinical presentation.

Bridging fungal resistance and plant growth through constitutive overexpression of Thchit42 gene in Pelargonium graveolens

This study overexpresses the Thchit42 gene in Pelargonium graveolens to enhance fungal resistance and plant growth, showing increased leaf size and oil content.

Oncogenic STIL-mediated loss of BRCA1 functionality causes DNA damage and centrosome amplification

This paper shows that STIL-mediated loss of BRCA1 functionality leads to DNA damage and centrosome amplification in cancer.

Developmental divergence in gene regulation among rapidly radiating cichlid species

This study examines gene regulation changes during development in cichlid fishes, finding species-specific expression patterns linked to trophic niche adaptation.

Multiomics analysis reveals B. MO1 as a distinct Babesia species and provides insights into its evolution and virulence.

The paper identifies B. MO1 as a distinct Babesia species through multiomics analysis, revealing genomic and functional differences from B. divergens and insights into their evolution and virulence.

Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection

This study develops and tests GmPcides, dihydrothiazolo ring-fused 2-pyridone compounds, showing efficacy against Streptococcus pyogenes SSTI and biofilm formation.

Plant metabolites modulate animal social networks and lifespan

This study shows that non-nutritive plant metabolites increase social interactions and reduce lifespan in turnip sawflies.

Vitamin B5 Metabolism is Essential for Vacuolar and Mitochondrial Integrity and Xenobiotic Detoxification in Fungi

This study shows that disrupting the PCA pathway in fungi affects vacuolar integrity, drug detoxification, and susceptibility to antifungal drugs, supporting its potential as a therapeutic target.

PLK4 homodimerization is required for CEP152 centrosome localization and spindle organization

This study shows that PLK4 homodimerization is essential for CEP152 localization to centrosomes and proper spindle organization, which is disrupted in cancer.

Gene co-expression patterns in Atlantic salmon adipose tissue provide a molecular link between seasonal changes, energy balance and age at maturity

The paper identifies gene co-expression patterns in Atlantic salmon adipose tissue linking seasonal changes, energy balance, and age at maturity through vgll3 genotype effects.

Histone Lactylation Drives CD8 T Cell Metabolism and Function

This study shows histone lactylation, specifically H3K18la and H3K9la, modulates CD8 T cell metabolism and function, impacting anti-tumor immunity.

Structural and functional vascular dysfunction within brain metastases is linked to pembrolizumab inefficacy

This study links structural and functional vascular dysfunction in brain metastases to pembrolizumab resistance by analyzing perfusion MRI data from 44 patients.

Integrative phenotypic-transcriptomic analysis of soybean plants subjected to multifactorial stress combination

This study investigates the effects of multifactorial stress combinations on soybean plants, revealing negative cumulative impacts and unique transcriptomic responses in different tissues.

Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling

The paper introduces a scalable organ-on-chip platform for high-throughput in vitro assays, demonstrating its use in modeling biological barriers and drug testing.

Vasodilators activate TMEM16A channels in endothelial cells to reduce blood pressure

Vasodilators stimulate TRPV4 channels, leading to calcium-dependent activation of nearby TMEM16A channels in endothelial cells to produce arterial hyperpolarization, vasodilation, and reduced blood pressure.

Consolidated Bioprocessing of Lignocellulosic Biomass Poplar to Produce Short-Chain Esters by Clostridium thermocellum

Rapid systemic responses of Arabidopsis to waterlogging stress

This study identifies rapid systemic ROS, calcium, and hydraulic wave responses in Arabidopsis to waterlogging stress, revealing their role in plant signaling and transcriptomic changes.

Kinome screening identifies integrated stress response kinase EIF2AK1 / HRI as a negative regulator of PINK1 mitophagy signaling

The paper identifies EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling through siRNA screening and pharmacological inhibition.

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

This study shows that O-GlcNAc modification of α-Synuclein leads to amyloid fibrils with reduced seeding activity and pathology in Parkinson's disease models.

A rapid method to quantify vein density in C4 plants using starch staining

The paper develops a high-throughput method to quantify vein density in C4 plants using starch staining and image analysis, finding variation in dicots but not in monocots.

System analysis of differentially expressed miRNAs in hexaploid wheat display tissue-specific regulatory role during Fe deficiency response

The paper identifies Fe deficiency-responsive miRNAs in hexaploid wheat and shows their tissue-specific regulation and potential targets involved in Fe homeostasis.