Author

P. Henneman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Y. F. Li Yim· 2 shared W. J. de Jonge· 2 shared A. Coffin· 1 shared A. Patel· 1 shared A. Shillings· 1 shared C. E. Blunt· 1 shared D. A. Zwijnenburg· 1 shared D. F. Tough· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersImmunology

A. Y. F. Li Yim

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2 papers

Recent·Most cited

Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140

M. Ghiboub, J. Koster, P. D. Craggs, A. Y. F. Li Yim, A. Shillings, S. Hutchinson, R. P. Bingham, K. Gatfield, I. L. Hageman, G. Yao, H. P. O'Keefe, A. Coffin, A. Patel, L. A. Sloan, D. J. Mitchell, , W. J. de Jonge

This study identifies SP140 as a druggable epigenetic reader and therapeutic target for Crohn's disease by showing that its inhibition reduces inflammatory macrophage activation and cytokine expression.

bioRxiv · Aug 10, 2020Immunology

Defining tissue- and disease-associated macrophages using a transcriptome-based classification model

H.-J. Chen, A. Y. F. Li Yim, G. R. Griffith, W. J. de Jonge, M. M. A. M. Mannens, E. Ferrero, P. Henneman, M. P. J. de Winther

This paper develops a classifier, macIDR, to identify macrophage subtypes from transcriptomic data and applies it to define tissue- and disease-specific macrophage characteristics.

bioRxiv · Jan 29, 2019Immunology