Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
J. Jacob, Y. Anami, P. High, Z. Liang, S. Subramanian, S. C. Ghosh, S. AghaAmiri, C. Guernsey-Biddle, H. Tran, J. H. Rowe, A. Azhdarinia, K. Tsuchikama, K. S. Carmon
This study develops and tests EREG-targeting ADCs showing efficacy in both RAS mutant and wildtype CRC, with high potency and safety in preclinical models.
bioRxiv · Feb 20, 2024 · PreprintCancer Biology