Author

P. J. Thomas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 2 Biophysics· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

A. LaPan· 1 shared A. S. Magaret· 1 shared A. S. Moffett· 1 shared A. Sivachenko· 1 shared A. Strang· 1 shared A. Thakerar Patel· 1 shared A. W. Eckford· 1 shared C. G. Wilson· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. LaPan

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Author profile →

5 papers

Recent·Most cited

COVID-19 and silent hypoxemia in a minimal closed-loop model of the respiratory rhythm generator

C. O. Diekman, P. J. Thomas, C. G. Wilson

The paper uses a computational model of the respiratory rhythm generator to investigate how altered chemosensory function contributes to silent hypoxemia in COVID-19 patients, finding that oxygen carrying capacity is the most significant factor.

Biological Cybernetics · Jun 17, 2024Peer-reviewedPhysiology

In Vitro Modulator Responsiveness of 655 CFTR Variants Found in People With CF

H. Bihler, A. Sivachenko, L. Millen, P. Bhatt, A. Thakerar Patel, J. Chin, V. Bailey, I. Musisi, A. LaPan, N. E. Allaire, J. Conte, N. R. Simon, A. S. Magaret, K. S. Raraigh, G. R. Cutting, , M. Mense

This study evaluates the responsiveness of 655 CFTR variants to the modulator therapy ELX/TEZ/IVA, identifying variants that show improved chloride transport function.

bioRxiv · Jul 7, 2023 · PreprintPharmacology & Toxicology

Inferring Density-Dependent Population Dynamics Mechanisms through Rate Disambiguation for Logistic Birth-Death Processes

L. Huynh, J. G. Scott, P. J. Thomas

The paper develops a method to disambiguate density-dependent mechanisms in birth-death processes using time series data, applied to understand drug resistance in cell populations.

bioRxiv · May 10, 2022Ecology

Noise source importance in linear stochastic models of biological systems that grow, shrink, wander, or persist

A. Strang, W. Huffmyer, H. Rollins, K. C. Abbott, P. J. Thomas

The paper develops a method to quantify the importance of noise sources in biological systems, showing how different noise contributions affect quantities of interest in various population dynamics scenarios.

bioRxiv · Jan 10, 2022 · PreprintEcology

Destructive and constructive cheater suppression through quorum sensing

A. S. Moffett, P. J. Thomas, M. Hinczewski, A. W. Eckford

This study shows quorum sensing can either harm or benefit bacterial populations depending on public good production costs and cheater presence.

bioRxiv · Jun 16, 2021 · PreprintBiophysics