Author

P. Karki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:E. coli· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

M. A. Orman· 2 shared A. Birukova· 1 shared A. Saba· 1 shared B. D. Keyesr· 1 shared C. C. Hong· 1 shared C. H. Williams· 1 shared C. Maracci· 1 shared F. Peske· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

M. A. Orman

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Author profile →

5 papers

Recent·Most cited

A Transient Metabolic State In Melanoma Persister Cells Mediated By Chemotherapeutic Treatments

P. Karki, V. Angardi, J. C. Mier, M. Orman

This study identifies a transient metabolic state in melanoma persister cells induced by chemotherapeutics, characterized by reduced Krebs cycle metabolite levels and increased mitochondrial ETC activity.

bioRxiv · Feb 21, 2021Cancer Biology

Coupling Metastasis to pH-Sensing GPR68 Using a Novel Small Molecule Inhibitor

C. H. Williams, L. R. Neitzel, P. Karki, T. E. Thayer, B. D. Keyesr, Q. S. Wells, J. A. Perry, K. Birukov, A. Birukova, C. C. Hong

This study identifies ogremorphin, a GPR68 inhibitor, and shows it reduces migration and invasion in melanoma cells, linking GPR68 proton-sensing to cancer metastasis.

bioRxiv · Jan 4, 2021 · PreprintCancer Biology

Therapeutically Exploring Persister Metabolism In Bacteria

S. G. Mohiuddin, T. Hoang, A. Saba, P. Karki, M. A. Orman

The paper identifies metabolic inhibitors that reduce bacterial persistence in Escherichia coli and Pseudomonas aeruginosa by targeting redox activities and intracellular degradation.

bioRxiv · Sep 10, 2019Microbiology

INVESTIGATING THE EFFECTS OF OSMOLYTES AND ENVIRONMENTAL pH ON BACTERIAL PERSISTERS

P. Karki, M. A. Orman

This study investigates how osmolytes and pH affect bacterial persisters in E. coli, finding that some chemicals and acidic pH reduce persisters, but late-stationary-phase cultures show less reduction and a positive correlation between growth and persister formation.

bioRxiv · Jul 4, 2019Microbiology

Dynamics of ribosomes and release factors during translation termination in E. coli

S. Adio, H. Sharma, T. Senyushkina, P. Karki, C. Maracci, W. Holtkamp, F. Peske, M. V. Rodnina

The paper investigates the dynamics of ribosome release factors RF1, RF2, and RF3 during translation termination in E. coli using single molecule FRET and ensemble kinetics.

bioRxiv · Jan 5, 2018Biochemistry