H. Sharma

Genome-Wide Identification of G-Quadruplex forming regions in Arabidopsis: Unraveling the Role of Pif like Helicase (AtPLH1) in Gene Regulation and Stress Response

This study identifies G-quadruplex regions in Arabidopsis and shows AtPLH1 regulates gene expression related to stress response and transcription.

A Mem-dELISA platform for dual color and ultrasensitive digital detection of colocalized proteins on extracellular vesicles

The paper introduces a Mem-dELISA platform for ultrasensitive, dual-color detection of colocalized proteins on extracellular vesicles, demonstrating its application in cancer research.

In vitro reconstitution reveals membrane clustering and RNA recruitment by the enteroviral AAA+ ATPase 2C

This study reconstitutes the membrane clustering and RNA recruitment functions of the enteroviral 2C protein in vitro, revealing its roles in viral replication and challenging its helicase function.

Kinase inhibitor-induced cell-type specific vacuole formation in the absence of canonical ATG5-dependent autophagy

This study shows that SB202190 induces cell-type specific vacuole formation independent of canonical autophagy, involving RAB7 and revealing potential therapeutic strategies.

Ribosome clustering and surface layer reorganization in the microsporidian host-invasion apparatus.

The paper uses microscopy and cryo-electron tomography to study the structural changes in microsporidian polar tubes during host invasion and identifies ribosome clustering in the cargo-filled state.

A Robust Deep Learning Approach for Joint Nuclei Detection and Cell Classification in Pan-Cancer Histology Images

This paper introduces TransNuc, a deep learning model for detecting and classifying cell nuclei in histology images, showing improved performance across various cancer types.

Probing metazoan polyphosphate biology using Drosophila reveals novel and conserved polyP functions

This study uses Drosophila to investigate polyphosphate (polyP) functions, revealing its role in hemolymph clotting and developmental timing, with implications for mammalian systems.

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

This study examines antibody and memory B cell responses after a third dose of SARS-CoV-2 mRNA vaccine, showing improved antibody quality and stable memory B cells capable of recognizing multiple variants.

Insights into the Human Gut Virome by Sampling a Population from the Indian Subcontinent

This study analyzes the gut virome of an Indian population using metagenomics, identifying novel viral families and a core virome composition.

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

This study shows that mRNA vaccination generates durable immune memory against SARS-CoV-2 and variants of concern, with continued evolution of B and T cell responses for at least 6 months.

Hemoglobin drives inflammation and initiates antigen spread and nephritis in lupus

This study shows that hemoglobin, particularly ferric hemoglobin, drives inflammation and autoantibody production in lupus by interacting with autoantigens and activating immune cells.

Differences in structure and hibernation mechanism highlight diversification of the microsporidian ribosome.

The paper presents the cryo-EM structure of the microsporidian ribosome from Paranosema locustae, revealing a unique hibernation mechanism and structural features of rRNA reduction.

Assembly Defects Abrogate Proofreading by Initiation Factors and License the Entry of Premature Ribosomes into the Translation Cycle

This study shows that E. coli ribosomes with assembly defects bypass proofreading steps and enter the translation cycle, leading to translation errors due to compromised decoding capabilities.

Dynamics of ribosomes and release factors during translation termination in E. coli

The paper investigates the dynamics of ribosome release factors RF1, RF2, and RF3 during translation termination in E. coli using single molecule FRET and ensemble kinetics.