Author

M. Orman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Klestzick· 1 shared A. Oza· 1 shared C. Hachicho· 1 shared C. L. Vizcarra· 1 shared C. M. Rojas· 1 shared D. Nambiar· 1 shared F. Bartolini· 1 shared J. C. Mier· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

A. Klestzick

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Metabolic disruption impairs ribosomal protein levels, resulting in enhanced aminoglycoside tolerance

R. Shiraliyev, M. Orman

This study shows that metabolic disruptions in E. coli increase aminoglycoside tolerance by upregulating TCA cycle proteins and affecting ribosomal components.

bioRxiv · Dec 20, 2023Microbiology

PROTON MOTIVE FORCE INHIBITORS ARE DETRIMENTAL TO METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS PERSISTER CELLS

S. G. Mohiuddin, S. Ghosh, P. Kavousi, M. Orman

This study shows PMF inhibitors can reduce MRSA persister cells by disrupting PMF and permeabilizing membranes, identifying effective compounds like nordihydroguaiaretic acid.

bioRxiv · May 24, 2022 · PreprintMicrobiology

Alterations to the broad-spectrum formin inhibitor SMIFH2 improve potency

M. Orman, M. Landis, A. Oza, D. Nambiar, J. Gjeci, K. Song, V. Huang, A. Klestzick, C. Hachicho, S. Q. Liu, J. M. Kamm, F. Bartolini, J. J. Vadakkan, C. M. Rojas, C. L. Vizcarra

The paper tests SMIFH2 and its derivatives against human formins, finding that modifications enhance potency but do not allow distinction between conserved FH2 domains.

bioRxiv · Mar 10, 2022 · PreprintBiochemistry

A Transient Metabolic State In Melanoma Persister Cells Mediated By Chemotherapeutic Treatments

P. Karki, V. Angardi, J. C. Mier, M. Orman

This study identifies a transient metabolic state in melanoma persister cells induced by chemotherapeutics, characterized by reduced Krebs cycle metabolite levels and increased mitochondrial ETC activity.

bioRxiv · Feb 21, 2021Cancer Biology