P. Kasson

Mechanistic dissection of antibody inhibition of influenza entry yields unexpected heterogeneity

This study develops a microfluidic assay to distinguish between attachment and fusion inhibition by antibodies against influenza hemagglutinin, revealing unexpected heterogeneity in neutralization mechanisms.

Measuring single-virus fusion kinetics using an assay for nucleic acid exposure

This paper develops a real-time assay to measure single-virus fusion kinetics and shows influenza virus fuses with liposomes of different sizes with similar kinetics.

Single-virus fusion measurements reveal multiple mechanistically equivalent pathways for SARS-CoV-2 entry

This study shows SARS-CoV-2 can use multiple protease-activated entry pathways, with fusion kinetics unaffected by protease identity or activation timing.

Precise triggering and chemical control of single-virus fusion within endosomes

This paper develops a method to precisely control single-virus fusion within endosomes using chemical triggers, enabling study of fusion dynamics under physiological conditions.

Antibiotic uptake across gram-negative outer membranes: better predictions towards better antibiotics

The paper develops a computational method and experimental assay to predict antibiotic uptake across gram-negative outer membranes, showing strong correlation between simulations and experimental permeability.