K. Okamoto

The ERAD ubiquitin ligase Doa10 negatively regulates Atg32-mediated mitophagy

The paper shows that Doa10, an ERAD ubiquitin ligase, interacts with Atg32 to regulate its degradation, thereby negatively controlling mitophagy in yeast.

High-throughput screening for Cushing's disease: therapeutic potential of thiostrepton via cell cycle regulation

This study identifies thiostrepton as a potential therapy for Cushing's disease by inducing cell cycle arrest in PitNETs through mechanisms independent of FOXM1.

High-resolution comparative atomic structures of two Giardiavirus prototypes infecting G.duodenalis parasite

This study presents high-resolution atomic structures of two Giardiavirus strains, revealing structural features associated with extracellular transmission and virulence in Giardia duodenalis.

Transcriptomic Landscape of Hyperthyroidism in Mice Overexpressing Thyroid Stimulating Hormone

This study analyzes the transcriptome of hyperthyroid mice overexpressing TSH, identifying novel genes and pathways associated with goiter development and thyroid hormone secretion.

qMaLioffG: A single green fluorescent protein FLIM indicator enabling quantitative imaging of endogenous ATP

The paper introduces qMaLioffG, a green fluorescent protein FLIM indicator that quantitatively measures endogenous ATP levels by detecting fluorescence lifetime changes in physiological ATP concentrations.

HIV viral protein R induces loss of DCT1-type renal tubules

This study shows HIV Vpr reduces DCT1-type renal tubules in mice, leading to salt wasting via apoptosis dysregulation of Slc12a3+ Pvalb+ cells.

Structure and its transformation of elliptical nege-like virus Tanay virus

This study determines the cryo-EM structure of Tanay virus and reveals its dynamic shape changes under different conditions, suggesting structural roles in infection and assembly.

A ubiquitin-proteasome pathway degrades the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis

The paper identifies the ubiquitin-proteasome pathway as a mechanism for degrading the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis.

Two closed conformations of CRAF require the 14-3-3 binding motifs and cysteine-rich domain to be intact in live cells

The paper uses smFRET to study CRAF conformational changes in live cells, identifying two closed conformations regulated by 14-3-3 binding and the cysteine-rich domain.

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

This study shows that PKR inhibition reduces mitochondrial dysfunction and ameliorates HIV-associated nephropathy in transgenic mice using single-nucleus and bulk RNA-seq.

Single-molecule tracking of Nanog and Oct4 in mouse embryonic stem cells

The paper tracks Nanog and Oct4 in mouse embryonic stem cells to study their roles in pluripotency, finding that Nanog interacts longer with targets during differentiation, suggesting a feedback mechanism.

Multifaceted effects of bycatch mitigation measures on target/non-target species for pelagic longline fisheries and consideration for bycatch management

The paper evaluates the effects of bycatch mitigation measures on target and non-target species in pelagic longline fisheries using Bayesian analysis of long-term data.

Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

This study investigates the dose-response relationship of pulmonary disorders caused by inhalation of CWAAP-A in rats, finding a LOAEC of 1 mg/m3 and reversible damage at 1 mg/m3 with gender differences in recovery.

Pathological characteristics of pulmonary toxicity in F344 rats exposed by inhalation to cross-linked water-soluble acrylic acid polymers

This study examines lung damage in rats exposed to cross-linked water-soluble acrylic acid polymers (CWAAPs) via inhalation and intratracheal instillation, finding similar pathological outcomes between exposure routes.

A full-length infectious cDNA clone of a dsRNA totivirus-like virus

The paper develops an infectious full-length DNA clone of a totivirus-like virus, OmRV, and demonstrates its ability to produce infectious particles with characteristics similar to the wild-type virus.

The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex

The paper shows the GET pathway regulates Atg32 phosphorylation and mitophagy by controlling Ppg1-Far localization and activity.

The 4.4 A structure of the giant Melbournevirus virion belonging to the Marseilleviridae family

The paper reports the 4.4 Å cryo-EM structure of the Melbournevirus capsid, revealing structural features and protein organization unique to the Marseilleviridae family.

The Effect of a Fennel Extract on the STAT Signaling and Intestinal Barrier Function

This study shows that fennel extract improves intestinal barrier function and reduces STAT pathway activation in both in vitro and in vivo models of inflammation.

Primordial capsid and spooled ssDNA genome structures penetrate ancestral events of eukaryotic viruses

The paper presents the capsid structure of a marine ssDNA virus and shows its genome is partially spooled, supporting horizontal gene transfer in its evolution.

A novel capsid protein network allows the characteristic inner membrane structure of Marseilleviridae giant viruses

The paper investigates the structure of tokyovirus, a Marseilleviridae giant virus, revealing a novel capsid protein network that forms its characteristic inner membrane structure.

FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.

This study shows FLT3-ITD accumulates in the Golgi apparatus in AML cells, activates signaling pathways like STAT5 and AKT/ERK during biosynthetic trafficking, and its tyrosine kinase activity is required for this retention.

Aberrant Epithelial Differentiation Contributes to Pathogenesis in a Murine Model of Congenital Tufting Enteropathy

This study shows that loss of EpCAM in CTE mice leads to altered intestinal cell differentiation, increasing absorptive cells and decreasing secretory cells, which can be partially reversed by DAPT treatment.

MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells

This study shows that MCM10 compensates for c-Myc-induced DNA replication stress in breast cancer stem-like cells, promoting genome duplication and drug resistance.

Precise triggering and chemical control of single-virus fusion within endosomes

This paper develops a method to precisely control single-virus fusion within endosomes using chemical triggers, enabling study of fusion dynamics under physiological conditions.

Electrospray sample injection for single-particle imaging with X-ray lasers

This paper demonstrates an electrospray injector that reduces aerosol droplet size, enabling contaminant-free sample delivery for single-particle imaging with X-ray lasers.

Lipid-protein interplay in dimerization of the juxtamembrane domains of epidermal growth factor receptor

The paper investigates how lipid-protein interactions and Thr654 phosphorylation regulate EGFR JM dimerization and kinase activity.

Cryo-EM Of A Marseilleviridae Virus Particle Reveals A Large Internal Microassembly

The paper presents a cryo-EM structure of the Marseilleviridae virus Melbournevirus, revealing a large internal microassembly and structural complexity.