Author

P. Kielkowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 6 Research Focus:cell type annotation· 5 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Organism:E. coli· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

R. Krafczyk· 2 shared S. Cappello· 2 shared T. Becker· 2 shared A. Hoffmann-Roeder· 1 shared A. Imhof· 1 shared A. M. Sieber· 1 shared A. Schaepers· 1 shared A. Schlundt· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

R. Krafczyk

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Author profile →

6 papers

Recent·Most cited

EF-P and its paralog EfpL (YeiP) differentially control translation of proline containing sequences

A. M. Sieber, M. Parr, J. von Ehr, K. Dhamotharan, P. Kielkowski, T. Brewer, A. Schaepers, R. Krafczyk, F. Qi, A. Schlundt, D. Frishman, J. Lassak

This study identifies EfpL as a ribosome rescue factor that senses cellular metabolic state, complementing EF-P in proline-containing sequence translation.

bioRxiv · Apr 15, 2024Microbiology

Decrypting the functional design of unmodified translation elongation factor P

U. Tomasiunaite, P. Kielkowski, R. Krafczyk, I. Forne, A. Imhof, K. Jung

This study identifies unmodified EF-P variants from Rhodomicrobium vannielii that restore function in E. coli lacking EF-P modifications, revealing design principles for polyproline synthesis.

bioRxiv · Sep 18, 2023Microbiology

Chemical Proteomics Reveals Protein Tyrosination Extends Beyond the Alpha-Tubulins in Human Cells.

D. Makarov, P. Kielkowski

The paper uses chemical proteomics to show that tyrosination extends beyond alpha-tubulins in human cells, including non-tubulin proteins like MAPRE1.

bioRxiv · Jul 2, 2022Biochemistry

Transforming chemical proteomics enrichment into high throughput method using SP2E workflow.

T. Becker, A. Wiest, A. Telek, D. Bejko, A. Hoffmann-Roeder, P. Kielkowski

The paper introduces an optimized workflow for high-throughput enrichment of post-translationally modified proteins, enabling efficient screening of proteoforms in specialized cell lines.

bioRxiv · Jan 24, 2022Biochemistry

AMPylation is a specific lysosomal protein posttranslational modification in neuronal maturation.

T. Becker, C. Cappel, F. Di Matteo, G. Sonsalla, E. Kaminska, F. Spada, S. Cappello, M. Damme, P. Kielkowski

The paper identifies AMPylation as a lysosomal posttranslational modification in neuronal maturation and shows it inhibits PLD3 activity.

bioRxiv · Mar 2, 2021 · PreprintBiochemistry

FICD activity and AMPylation remodelling modulate human neurogenesis.

P. Kielkowski, I. Y. Buchsbaum, V. C. Kirsch, N. C. Bach, S. Cappello, M. Drukker, S. A. Sieber

This study investigates the role of AMPylation in human neurogenesis by identifying modified proteins and showing FICD-dependent AMPylation accelerates neural progenitor cell differentiation into neurons.

bioRxiv · Nov 26, 2019Biochemistry