T. Becker

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T-cell recognition by targeting CIITA

This study identifies pUS28 as a viral protein that inhibits CIITA-driven HLA-II expression, thereby blocking CD4+ T-cell recognition of HCMV-infected cells.

Role of the small protein Mco6 in the mitochondrial sorting and assembly machinery

This study identifies Mco6 as a component of the mitochondrial sorting and assembly machinery, showing its interaction with Mdm10 and Mim1 and its role in TOM complex assembly.

Mitochondrial protein import clogging as a mechanism of disease

The paper shows that mutations in mitochondrial preproteins cause clogging of the import pathway, leading to disease by impairing mitochondrial function and cell viability.

The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex

This study shows that Ubc8 promotes mitochondrial protein import by enhancing TOM complex assembly during metabolic transitions in yeast.

Clearing of ribosome collisions by the ribosome quality control trigger complex RQT

The paper shows RQT clears collided ribosomes by pulling mRNA to trigger destabilizing conformational transitions for subunit dissociation.

Transforming chemical proteomics enrichment into high throughput method using SP2E workflow.

The paper introduces an optimized workflow for high-throughput enrichment of post-translationally modified proteins, enabling efficient screening of proteoforms in specialized cell lines.

AMPylation is a specific lysosomal protein posttranslational modification in neuronal maturation.

The paper identifies AMPylation as a lysosomal posttranslational modification in neuronal maturation and shows it inhibits PLD3 activity.

Marmoset monkeys (Callithrix jacchus) develop eosinophilic airway inflammation after house dust mite exposure

This study shows marmoset monkeys develop eosinophilic airway inflammation after house dust mite exposure, useful for testing new human-specific biologicals.

Machine Learning Analysis of Motor Evoked Potential Time Series to Predict Disability Progression in Multiple Sclerosis

This study uses machine learning to analyze motor evoked potential time series and predict disability progression in multiple sclerosis, finding modest performance improvements with additional features.

Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts

This study identifies molecular mechanisms of translational stalling caused by inhibitory codon pairs and poly(A) tracts using in vitro biochemistry, ribosome profiling, and cryo-EM.

A novel mitochondrial enriched antioxidant protects neurons against acute oxidative stress

This study identifies Proxison, a novel flavonoid antioxidant, showing enhanced neuroprotection against oxidative stress in vitro and in a zebrafish model.