A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells
M. J. K. Jones, S. K. Rai, P. L. Pfuderer, A. Bonfim-Melo, J. K. Pagan, P. R. Clarke, S. E. McClelland, M. A. Boemo
This paper introduces an AI-powered nanopore sequencing method to measure DNA replication stress in cancer cells, showing it can distinguish fork slowing from stalling and detect therapy-specific replication stress signatures.
bioRxiv · Sep 22, 2022Cancer Biology