Cancer BiologybioRxiv
A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells
M. J. K. Jones, S. K. Rai, P. L. Pfuderer…·M. A. Boemo
This paper introduces an AI-powered nanopore sequencing method to measure DNA replication stress in cancer cells, showing it can distinguish fork slowing from stalling and detect therapy-specific replication stress signatures.
DOI 10.1038/s41467-025-63168-w