Mechanical control of the splicing factor PTBP1 regulates extracellular matrix stiffness-induced cell proliferation and mechanomemory
K. S. Erdmann, P. L. Tseng, W. Sun, A. Salem, S. Macfarlane, A. K. Gad, M. Collins
This study identifies PTBP1 as a mechanotransducer that regulates cell proliferation and mechanomemory through mechanosensitive splicing of Numb in response to extracellular matrix stiffness.
bioRxiv · May 7, 2024 · PreprintCell Biology