M. Collins

Mechanical control of the splicing factor PTBP1 regulates extracellular matrix stiffness-induced cell proliferation and mechanomemory

This study identifies PTBP1 as a mechanotransducer that regulates cell proliferation and mechanomemory through mechanosensitive splicing of Numb in response to extracellular matrix stiffness.

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor

This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

The BR-body proteome contains a complex network of protein-protein and protein-RNA interactions

The paper identifies 111 proteins enriched in bacterial RNP bodies (BR-bodies) and shows they form a complex network of protein-protein and protein-RNA interactions that regulate BR-body phase separation and RNA processing.

The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages

This paper shows neratinib induces neutrophil apoptosis and enhances macrophage clearance in acute lung injury, supported by phosphoproteomics analysis.

HDAC6 inhibitor ACY-1083 shows lung epithelial protective features in COPD

This study shows that HDAC6 inhibitor ACY-1083 protects lung epithelial function in COPD by reducing permeability and cytokine production under various challenges.

Cell Surface-Bound La Protein Regulates The Cell Fusion Stage Of Osteoclastogenesis

The paper identifies La protein as a cell surface regulator of osteoclast fusion, showing its role in bone metabolism and potential as a therapeutic target.

Plasma cell maintenance and antibody secretion are under the control of Sec22b-mediated regulation of organelle dynamics

This study identifies Sec22b as a critical regulator of plasma cell maintenance and function by controlling organelle dynamics, leading to reduced antibody secretion and impaired immune response.

PGfinder, a novel analysis pipeline for the consistent, reproducible and high- resolution structural analysis of bacterial peptidoglycans

PGfinder provides an automated pipeline for high-resolution structural analysis of bacterial peptidoglycans, enabling consistent and reproducible quantification of PG fragments and discovery of novel structural features.

Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro

This study identifies three phases of hepatocyte dedifferentiation in culture through RNA-seq and ATAC-seq, revealing rapid chromatin changes and fetal gene activation.

Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells

This study shows that keratin 19 maintains E-cadherin at the cell surface, stabilizes cell-cell adhesion, and influences migration and colony formation in MCF7 cells.

The Effects of Sex and Strain on Pneumocystis murina Fungal Burdens in Mice

This study shows female mice have higher Pneumocystis murina infection burdens than males at later time points across three strains.

Non-uniform Crowding Enhances Transport: Relevance to Biological Environments

The paper shows that non-uniform crowder distributions enhance tracer transport in biological environments, with implications for intracellular transport mechanisms.

In vitro activity of a novel antifungal compound, MYC-053, against clinically significant antifungal-resistant strains of Candida glabrata, Candida auris, Cryptococcus neoformans, and Pneumocystis spp.

This study evaluates the antifungal activity of MYC-053 against resistant fungal strains and shows its effectiveness against biofilms and lack of toxicity.

The dental calculus metabolome in modern and historic samples

This study characterizes the metabolome of modern and historic dental calculus to identify patterns of metabolite persistence and loss over time.