W. Sun

Histone marks enable formation of immiscible phase-separated chromatin compartments

The paper shows that histone marks drive phase-separated chromatin compartments, influencing gene expression and cancer progression through the CBX7-PRC1 complex.

The m6A Reader ECT1 Mediates Seed Germination via the DAG2-ECT1-PHYB Regulatory Cascade in Arabidopsis

This study identifies ECT1 as an m6A reader protein that promotes seed germination in Arabidopsis through a DAG2-ECT1-PHYB regulatory cascade involving transcriptional and post-transcriptional control.

Lipid droplets restrict phagosome formation during Candida challenge

This study shows that lipid droplets restrict phagosome formation in macrophages during Candida infection, protecting cells from death and offering a potential drug target.

Preventing trogocytosis by cathepsin B inhibition augments CAR T cell function

This study shows that inhibiting cathepsin B prevents CAR T cell fratricide and exhaustion by blocking trogocytosis, improving CAR T cell persistence and anti-tumor activity.

An empirical evaluation of simulated gastrointestinal digestion platforms for use in plant breeding, using common bean (Phaseolus vulgaris L.) as a model

This study evaluates simulated digestion models to assess bioaccessible nutrient levels in common bean, finding dynamic models outperform static ones in predicting nutrient release.

Mechanical control of the splicing factor PTBP1 regulates extracellular matrix stiffness-induced cell proliferation and mechanomemory

This study identifies PTBP1 as a mechanotransducer that regulates cell proliferation and mechanomemory through mechanosensitive splicing of Numb in response to extracellular matrix stiffness.

Curved light sheet microscopy for centimeter-scale cleared tissues imaging

The paper introduces a curved light sheet microscope for high-throughput imaging of cleared tissues, achieving diffraction-limited resolution over a large field of view.

Humanized in vivo bone marrow models orchestrate multi-lineage human hematopoietic cell development

This study characterizes a humanized in vivo bone marrow model, hOss, showing its impact on human hematopoietic development and clonal interactions.

Structure and function of an intermediate GPCR-G protein complex

The paper resolves the structure of an intermediate GPCR-G protein complex and shows it initiates nucleotide exchange without progressing to the fully activated state, providing insights into GPCR signaling complexity.

Testing a Method for Quantifying Microplastic Content in Mytilus californianus

The paper tests a method to isolate and quantify microplastics in Mytilus californianus using digestion, sonication, and fluorescent microscopy.

Newcastle Disease Virus Vector-Based SARS-CoV-2 Vaccine Candidate AVX/COVID-12 Activates T Cells and Is Recognized by Antibodies from COVID-19 Patients and Vaccinated

This paper evaluates the AVX/COVID-12 vaccine's ability to activate T cells and bind antibodies from vaccinated individuals and SARS-CoV-2-infected patients.

Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination

This study identifies non-neutralizing antibodies from vaccinated individuals that protect against SARS-CoV-2 in animal models, highlighting their role through Fc-mediated effector functions and conserved epitope binding.

OCA-B/Pou2af1 is sufficient to promote CD4+ T cell memory and prospectively identifies memory precursors

This study shows that OCA-B expression promotes CD4+ T cell memory and identifies memory precursor cells using a reporter mouse line.

Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

Restricting CAR T Cell Trafficking Expands Targetable Antigen Space

The paper shows that modifying integrin-mediated adhesion in CAR T cells prevents CNS targeting while maintaining anti-tumor activity against Ewing sarcoma.

Intermittent energy restriction inhibits tumor growth and enhances paclitaxel response in a transgenic mouse model of endometrial cancer

This study shows that intermittent energy restriction (IER) reduces tumor growth and improves paclitaxel response in a mouse model of endometrial cancer compared to low-fat diet.

Differential activation of rhodopsin triggers distinct endocytic trafficking and recycling in vivo via differential phosphorylation

This study shows that differential activation of rhodopsin via blue or green light leads to distinct endocytic trafficking and recycling pathways in flies, mediated by different phosphorylation patterns and interactions with arrestin.

Integrated Hfq-interacting RNAome and transcriptomic analysis reveals complex regulatory networks of nitrogen fixation in root-associated Pseudomonas stutzeri A1501

This study identifies Hfq-binding RNAs in Pseudomonas stutzeri A1501 using eCLIP-seq, revealing new regulatory targets involved in nitrogen fixation and other metabolic processes.

Phylogeny-metabolism dual-directed single-cell genomics for dissecting and mining ecosystem function

This paper introduces FISH-scRACS-Seq, a method to identify and sequence single cells with specific metabolic functions, revealing a new cyclohexane-degrading enzyme system in marine bacteria.

IsoVEM: Isotropic Reconstruction for Volume Electron Microscopy Based on Transformer

The paper introduces IsoVEM, a transformer-based algorithm for isotropic reconstruction in volume electron microscopy, improving axial resolution and repairing damaged sections.

Biomechanical stress analysis of Type-A aortic dissection at pre-dissection, post-dissection, and post-repair states

This study uses finite element analysis on CT images to analyze biomechanical stress changes in aortic dissection across pre-dissection, post-dissection, and post-repair states, revealing increased wall stress and stress concentration regions.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

Pseudorabies virus causes splenic injury via inducing the oxidative stress and apoptpsos related factors in mice

This study shows PRV infection increases oxidative stress and apoptosis in mouse spleen, with elevated ROS and MDA levels and reduced antioxidant enzymes.

Pneumonic plague protection induced by a monophosphoryl lipid A decorated Yersinia outer-membrane-vesicle vaccine

This study develops a pneumonic plague vaccine using OMV46-LcrV, which shows reduced reactogenicity and complete protection in mice against Y. pestis challenge.

The role of neutrophil typing in homeostatic resilience protective model of inflammatory preconditioning

This study investigates the role of IRF4 and IRF5 in neutrophil response during septic peritonitis, showing their involvement in PMN phenotype switching and inflammatory outcomes.

Distinct Microstructural Heterogeneities Underpin Specific Micromechanical Properties in Human ACL Femoral and Tibial Entheses

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy

The paper examines HIV-1 provirus persistence in CNS tissues during ART by analyzing multiple anatomical compartments in treated individuals.

Human subcutaneous adipose tissue variability is driven by VEGFA, ACTA2, adipocyte density, and ancestral history of the patient

This study identifies key factors driving variability in human subcutaneous adipose tissue, including VEGFA, ACTA2, adipocyte density, and patient ancestry.

Single-cell RNA-sequencing identifies a novel subset of CD9+ reparative macrophages modulated by CCN2 derived from Nlrx1 deficient cardiomyocytes in the infarcted heart

The paper identifies a novel CD9+Il1rn+ reparative macrophage subset in infarcted hearts modulated by CCN2 from Nlrx1-deficient cardiomyocytes, showing potential therapeutic implications for myocardial healing.

Synergistic Integration of Deep Neural Networks and Finite Element Method with Applications for Biomechanical Analysis of Human Aorta

This paper integrates deep neural networks with finite element methods to improve biomechanical analysis of the human aorta, reducing errors and computational time.