Development and application of genetic ancestry reconstruction methods to study diversity of patient-derived models in the NCI PDXNet Consortium
B. J. Sanderson, P. Lott, K. Chiu, J. E. Quino, A. P. Vang, M. W. Lloyd, A. Srivastava, PDXNet Consortium, J. H. Chuang, L. G. Carvajal-Carmona
The paper develops a genetic ancestry pipeline to assess diversity in PDX models and finds overrepresentation of European ancestry models, highlighting gaps in minority representation for cancer research.
bioRxiv · Oct 24, 2022 · PreprintCancer Biology