Author

C. Frech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:whole-exome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Srivastava· 3 shared B. Davis-Dusenbery· 3 shared D. A. Dean· 3 shared A. L. Welm· 2 shared C. J. Bult· 2 shared F. Meric-Bernstam· 2 shared J. A. Moscow· 2 shared J. DiGiovanna· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. Srivastava

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4 papers

Recent·Most cited

PDXNet Portal: Patient-Derived Xenograft model, data, workflow, and tool discovery

S. Koc, M. W. Lloyd, J. Grover, S. Seepo, S. Lakshmi Subramanian, M. Ray, C. Frech, J. DiGiovanna, P. Webster, S. Neuhauser, A. Srivastava, X. Yi Woo, B. J. Sanderson, B. White, P. Lott, , J. H. Chuang

The paper introduces the PDXNet Portal, a centralized resource for PDX models and data, offering analysis workflows and facilitating cancer research collaboration.

bioRxiv · Oct 15, 2021Cancer Biology

Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8

T. Weiss, S. Taschner-Mandl, A. Bileck, F. Rifatbegovic, H. Sorger, M. Kauer, C. Frech, R. Windhager, C. Gerner, P. F. Ambros, I. M. Ambros

This study shows that Schwann cells in neuroblastic tumors and injured nerves share repair-related functions, with EGFL8 promoting neuronal differentiation of tumor cells.

Nature Communications · Mar 12, 2021Peer-reviewedCancer Biology

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

X. Y. Woo, J. Giordano, A. Srivastava, Z.-M. Zhao, M. W. Lloyd, R. de Bruijn, Y.-S. Suh, R. Patidar, L. Chen, S. Scherer, M. Bailey, C.-H. Yang, E. Cortes-Sanchez, Y. Xi, J. Wang, , B. E Welm

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.

bioRxiv · Dec 3, 2019Cancer Biology

Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis

Y. A. Evrard, A. SRIVASTAVA, J. Randjelovic, S. Arunachalam, C. J. Bult, H. Chen, L. Chen, M. Davies, S. Davies, B. Davis-Dusenbery, J. DiGiovanna, L. Ding, J. H. Doroshow, B. Fang, C. Frech, , J. Morris

The paper tests the reproducibility of PDX drug responses and sequence results across different labs using standardized protocols and workflows.

bioRxiv · Oct 2, 2019Cancer Biology