Non-cancer stem cell-derived Fibromodulin activates Integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth
K. Somasundaram, S. Sengupta, M. Mondal, K. R. Prasasvi, A. Mukherjee, P. Magod, S. Urbach, D. Friedmann-Morvinski, P. Marin
This study shows that Fibromodulin from non-cancer stem cells promotes glioma tumor growth by activating Notch signaling in endothelial cells through integrin-dependent paracrine signaling.
bioRxiv · Apr 3, 2022Cancer Biology