Human liver organoids; a patient-derived primary model for HBV Infection and Related Hepatocellular Carcinoma
E. De Crignis, S. Romal, F. Carofiglio, P. Moulos, M. M. A. Verstegen, M. M. Khalid, F. Pourfarzad, S. Rao, A. Bazrafshan, C. Koutsothanassis, H. Gehart, T. W. Kan, R.-J. Palstra, C. Boucher, J. IJzermans, , T. Mahmoudi
This paper establishes human liver organoids as a model for HBV infection and HCC, showing they support viral replication, produce infectious HBV, and exhibit cancer-related gene signatures.
bioRxiv · Nov 11, 2020Cancer Biology