M. M. Khalid

Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants

This study shows ORF8 suppresses viral particle production by interacting with Spike and causing Golgi fragmentation, supporting evolutionary pressure to delete ORF8 in SARS-CoV-2 variants.

Assembly reactions of SARS-CoV-2 nucleocapsid protein with nucleic acid

This study investigates the assembly of SARS-CoV-2 nucleocapsid protein with nucleic acids using biophysical techniques and mutant proteins, revealing key interaction motifs and stabilization mechanisms.

Colloidal aggregation confounds cell-based Covid-19 antiviral screens

The paper investigates how colloidal aggregation affects cell-based antiviral screens for Covid-19 drugs, finding that aggregation reduces antiviral potency and suggests a non-specific mechanism.

Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6

The paper introduces a plasmid-based method to assemble SARS-CoV-2 genomes and identifies NSP6 mutations as causing Omicron attenuation.

SARS-CoV-2 ORF8 limits expression levels of Spike antigen.

This study identifies ORF8 as a SARS-CoV-2 protein that reduces Spike antigen levels on infected cells, thereby limiting antibody recognition and immune evasion.

NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

The paper uses ACE2-overexpressing airway organoids to show NF-κB inhibitor alpha is upregulated during SARS-CoV-2 infection and its reduced function increases viral infection.

Hepatitis C Virus Infects and Perturbs Liver Stem Cells

This study identifies liver stem cells as targets of HCV infection, showing their transcriptional reprogramming and role in liver damage and cancer risk.

Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles

This study uses SARS-CoV-2 virus-like particles to rapidly assess mutations in viral variants, finding that N protein mutations enhance RNA packaging and viral spread.

Zika Virus Infection Prevents Host mRNA Nuclear Export by Disrupting UPF1 Function

This study shows ZIKV infection disrupts UPF1 function, leading to nuclear mRNA accumulation and impaired neural progenitor cell function.

Human liver organoids; a patient-derived primary model for HBV Infection and Related Hepatocellular Carcinoma

This paper establishes human liver organoids as a model for HBV infection and HCC, showing they support viral replication, produce infectious HBV, and exhibit cancer-related gene signatures.

The cellular NMD pathway restricts Zika virus infection and is targeted by the viral capsid protein

This study shows that ZIKV infection disrupts the NMD pathway by interacting with UPF1 via its capsid protein, enhancing viral infection and contributing to neuropathology.