CircPVT1 sponges miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer
A. C. Palcau, C. Pulito, V. De Pascale, L. Casadei, M. C. Valerio, A. Sacconi, D. Rutigliano, S. Donzelli, R. F. Auciello, F. Pimpinelli, P. Muti, C. Botti, S. Strano, G. Blandino
This study identifies circPVT1 as a regulator of metabolic pathways in breast cancer by sponging miR-33a-5p, leading to increased c-MYC and GLS1 activity and promoting tumorigenesis.
bioRxiv · Jun 4, 2024 · PreprintCancer Biology