Balancing positive and negative selection: in vivo evolution of Candida lusitaniae MRR1
E. G. Demers, J. E. Stajich, A. Ashare, P. Occhipinti, D. A. Hogan
The paper analyzes MRR1 allele evolution in Candida lusitaniae isolates from a chronic infection, revealing tradeoffs between high Mrr1 activity conferring antifungal resistance and hydrogen peroxide resistance.
bioRxiv · Nov 30, 2020Microbiology