D. A. Hogan

How individual P. aeruginosa cells with diverse stator distributions collectively form a heterogeneous macroscopic swarming population

The paper shows that P. aeruginosa cells with different stator distributions create a heterogeneous swarming population through dynamic stator recruitment and motor intermittency.

Loss of LasR function leads to decreased repression of Pseudomonas aeruginosa PhoB activity at physiological phosphate concentrations

This paper shows that loss of LasR function in Pseudomonas aeruginosa increases PhoB activity at physiological phosphate concentrations, contributing to increased virulence.

Widespread fungal-bacterial competition for magnesium enhances antibiotic resistance

Fungi sequester magnesium from bacteria, reducing their fitness but increasing antibiotic resistance to colistin.

Analysis of Pseudomonas aeruginosa transcription in an ex vivo cystic fibrosis sputum model identifies metal restriction as a gene expression stimulus

The paper analyzes Pseudomonas aeruginosa gene expression in CF sputum and identifies metal restriction as a key driver of gene expression variation across donors.

Citrate cross-feeding between Pseudomonas aerguinosa genotypes supports lasR mutant fitness

The paper identifies citrate cross-feeding between Pseudomonas aeruginosa genotypes as a mechanism that enhances fitness and virulence in lasR mutant strains.

Citrate cross-feeding between Pseudomonas aerguinosa genotypes supports lasR mutant fitness in co-cultures

The paper shows that citrate cross-feeding between Pseudomonas aeruginosa genotypes enhances fitness of lasR mutants in co-cultures by enabling citrate uptake and virulence factor expression.

Mrs4 loss of function in fungi during adaptation to the cystic fibrosis lung

The paper identifies MRS4 mutations in fungi associated with cystic fibrosis lung infections, showing they confer a fitness advantage by enhancing iron acquisition in iron-limited environments.

In host evolution of Exophiala dermatitidis in cystic fibrosis lung micro-environment

The paper analyzes genomic and phenotypic variation in Exophiala dermatitidis isolates from a CF patient over two years, identifying clades with distinct mutations and functional traits.

Transcriptional response of Candida auris to the Mrr1 inducers methylglyoxal and benomyl

This study identifies MRR1a as a key regulator of methylglyoxal resistance in C. auris, showing it co-regulates an MG reductase and an efflux pump, and reveals a hyperactive Mrr1 variant in a specific clade.

Computationally efficient assembly of a Pseudomonas aeruginosa gene expression compendium

The paper processes and normalizes thousands of Pseudomonas aeruginosa RNA-seq datasets to enable cross-experiment comparisons and hypothesis testing.

Non-motile subpopulations of Pseudomonas aeruginosa repress flagellar motility in motile cells through a type IV pili- and Pel-dependent mechanism

The paper shows non-motile Pseudomonas aeruginosa cells repress swarming motility in motile cells via type IV pili and Pel exopolysaccharide.

Tobramycin-induced secretion of P. aeruginosa 5' tRNA-fMet halves suppresses lung inflammation via AGO2 gene silencing

This study shows tobramycin reduces lung inflammation in pwCF by increasing 5' tRNA-fMet halves that suppress IL-8 and neutrophil recruitment via AGO2 gene silencing.

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway

This study identifies Ssn3 kinase substrates involved in hyphal growth repression through Flo8 phosphorylation in C. albicans.

Calprotectin-mediated zinc chelation inhibits Pseudomonas aeruginosa protease activity in cystic fibrosis sputum

This study shows that calprotectin chelates zinc to inhibit Pseudomonas aeruginosa protease activity in cystic fibrosis sputum, revealing a mechanism for zinc-dependent virulence regulation.

Balancing positive and negative selection: in vivo evolution of Candida lusitaniae MRR1

The paper analyzes MRR1 allele evolution in Candida lusitaniae isolates from a chronic infection, revealing tradeoffs between high Mrr1 activity conferring antifungal resistance and hydrogen peroxide resistance.

Pseudomonas aeruginosa and Candida albicans both accumulate greater biomass in dual species biofilms under flow

This study shows that Pseudomonas aeruginosa and Candida albicans accumulate more biomass in dual-species biofilms under flow compared to single-species biofilms.

Conditional antagonism in co-cultures of Pseudomonas aeruginosa and Candida albicans: an intersection of ethanol and phosphate signaling distilled from dual-seq transcriptomics

This study identifies ethanol and phosphate signaling interactions between Pseudomonas aeruginosa and Candida albicans using dual RNA-seq, revealing conditional antagonism mediated by PhoB and Pho4.

Mrr1 regulation of methylglyoxal catabolism and methylglyoxal-induced fluconazole resistance in Candida lusitaniae

This study shows Mrr1 regulates methylglyoxal detoxification and fluconazole resistance in Candida lusitaniae, with methylglyoxal inducing MDR1 expression and enhancing fluconazole tolerance.

Intra-species signaling between distinct Pseudomonas aeruginosa genotypes increases production of quorum sensing controlled virulence factors

The paper shows that interactions between Pseudomonas aeruginosa genotypes with different LasR function increase virulence factor production through reciprocal signaling.

Pseudomonas aeruginosa lasR mutant fitness in microoxia is supported by an Anr-regulated oxygen-binding hemerythrin

This paper identifies an Anr-regulated hemerythrin, Mhr, that enhances fitness of Pseudomonas aeruginosa lasR mutants in microoxic conditions by binding oxygen.

Phenotypic differences in reversible attachment behavior reveal distinct P. aeruginosa surface colonization strategies

The paper examines reversible attachment behavior in P. aeruginosa strains PAO1 and PA14, revealing distinct surface colonization strategies through single-cell tracking and stochastic modeling.

Ethanol stimulates trehalose production through a SpoT-DksA-AlgU dependent pathway in Pseudomonas aeruginosa

This paper shows ethanol induces trehalose production in Pseudomonas aeruginosa via a SpoT-DksA-AlgU pathway and AHL quorum sensing, dependent on growth phase.

Pseudomonas aeruginosa ethanol oxidation by AdhA in low oxygen environments

This study identifies AdhA as a key enzyme for ethanol oxidation in Pseudomonas aeruginosa under low oxygen conditions, leading to acetate production and enhanced survival.

Ethanol decreases Pseudomonas aeruginosa flagellar motility through a cyclic-di-GMP- and stator-dependent pathway

This study shows ethanol reduces Pseudomonas aeruginosa motility by increasing c-di-GMP and involving stator and PilMNOP proteins.

Refining the application of microbial lipids as tracers of Staphylococcus aureus growth rates in cystic fibrosis sputum

This study refines the use of microbial lipids as growth rate tracers for Staphylococcus aureus in CF sputum by identifying alternative microbial sources of fatty acids and recommending best practices for stable isotope probing.

Profiling of bacterial and fungal microbial communities in cystic fibrosis sputum using RNA

This paper introduces a method to detect bacterial and fungal taxa in CF sputum using RNA-based NanoString probes, showing taxon-specificity and linear response over three logs of input RNA.