Novel Mechanism for Tubular Injury in Nephropathic Cystinosis
S. Sur, M. Kerwin, S. Pineda, P. Sansanwal, T. K. Sigdel, M. Sirota, M. M. Sarwal
This study identifies ATP6V0A1 downregulation in cystinosis as a key factor in tubular injury, showing that antioxidants like astaxanthin can restore mitochondrial function and autophagosome turnover.
bioRxiv · May 13, 2022Cell Biology