S. Sur

Allosteric inhibition of CXCR1 and CXCR2 abrogates Th2/Th17-associated Allergic Lung Inflammation in Mice

This study shows that inhibiting CXCR1 and CXCR2 reduces Th2/Th17-driven allergic lung inflammation in mice by blocking cell recruitment and cytokine expression.

Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

A SMG1 inhibitor disrupts nonsense-mediated decay, increasing expression of neoantigens from truncating mutations and enhancing immune targetable peptides on cancer cells.

ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

ME3BP-7 is a novel 3BP formulation that resists serum degradation and kills MCT1-high pancreatic cancer cells with low toxicity in mice.

Application of nanopore sequencing for accurate identification of bacterial colonies

This study compares Sanger and nanopore sequencing for identifying bacterial colonies from bioaerosol samples, finding nanopore sequencing more accurate in multispecies colonies.

Plasma Proteome Perturbation for CMV DNAemia in Kidney Transplantation

The paper identifies plasma proteomic changes associated with CMV DNAemia in kidney transplant recipients, revealing biomarkers for disease prediction and immune pathway insights.

Implications of Spike Protein Interactions with Zn-bound form of ACE2: A Computational Structural Study

This study investigates the impact of excluding a zinc ion from ACE2-S1 protein complex simulations, finding that Zn-bound complexes show greater stability and stronger binding free energy.

Novel Mechanism for Tubular Injury in Nephropathic Cystinosis

This study identifies ATP6V0A1 downregulation in cystinosis as a key factor in tubular injury, showing that antioxidants like astaxanthin can restore mitochondrial function and autophagosome turnover.

Circulatory exosomes from COVID-19 patients trigger NLRP3 inflammasome in endothelial cells

This study shows that exosomes from severe COVID-19 patients activate the NLRP3 inflammasome in endothelial cells, leading to increased IL-1β secretion.

Effects of Cholesterol on the mechanism of fengycin, a biofungicide

This study uses molecular dynamics simulations to show cholesterol reduces fengycin aggregation and membrane disruption.

Modeling Substrate Coordination to Zn-Bound Angiotensin Converting Enzyme 2

This study computationally designs Ang II mutants to identify strong ACE2 binders and examines their stability and binding energy using molecular dynamics simulations.

Exosomes from COVID-19 patients carry tenascin-C and fibrinogen-β in triggering inflammatory signals in distant organ cells

This study identifies tenascin-C and fibrinogen-β in exosomes from COVID-19 patients that trigger pro-inflammatory cytokine expression in distant organ cells.

Precision Sub-phenotyping of Histologically Stable Kidney Transplants by a Composite Molecular and Cellular Instability Score

The paper develops a molecular and cellular instability score to reclassify histologically stable kidney allografts, identifying those with molecular signatures of acute rejection and predicting clinical outcomes.