T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type-1 cells
J. Garnica, P. Sole, J. Yamanouchi, J. Moro, D. Mondal, C. Fandos, P. Serra, P. Santamaria
The paper investigates the epigenetic mechanisms enabling T-follicular helper cells to transdifferentiate into TR1 cells, finding that TR1 gene programs are pre-established in TFH cells.
bioRxiv · May 17, 2024Immunology