A. Jimenez

Murine modeling of menstruation identifies immune correlates of protection during Chlamydia muridarum challenge.

This study uses a murine menstruation model to show that NK cell infiltration during endometrial remodeling protects against Chlamydia muridarum infection.

Detuning of the Ribosome Conformational Landscape Promotes Antibiotic Resistance and Collateral Sensitivity

The paper identifies a ribosome mutation that causes antibiotic resistance by altering conformational dynamics and reveals new tobramycin binding sites, leading to collateral sensitivity to chloramphenicol.

A multiadjuvant polysaccharide-amino acid-lipid (PAL) subunit nanovaccine generates robust systemic and lung-specific mucosal immune responses against SARS-CoV-2 in mice

This study develops a mucosal nanovaccine that enhances both systemic and lung-specific immunity against SARS-CoV-2 in mice through intranasal and intramuscular delivery.

High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation

This paper introduces eSRRF, an enhanced super-resolution imaging method that improves image fidelity and extends to 3D imaging using multi-focus microscopy.

Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension

This study shows senescent stroma reduces cancer cell nuclear tension via RhoA/ROCK/myosin II inhibition, leading to morphological changes linked to malignancy.

Antibody Conversion rates to SARS-CoV-2 in Saliva from Children Attending Summer Schools in Barcelona, Spain

The paper assesses SARS-CoV-2 antibody conversion rates in children and adults via saliva samples, finding higher conversion in adults and a protective role of anti-spike antibodies.

Race specific differences in DNA damage repair dysregulation in breast cancer and association with outcome

The paper identifies race-specific DNA damage repair (DDR) gene dysregulation patterns in African American (AA) ER+ breast cancer patients and links them to poorer survival outcomes.

Single-Cell Transcriptomic Attributes and Unbiased Computational Modeling for the Prediction of Immunomodulatory Potency of Mesenchymal Stromal Cells

This study uses single-cell RNA-seq and computational models to identify transcriptomic attributes predicting immunomodulatory potency of mesenchymal stromal cells.

Highly sensitive and specific multiplex antibody assays to quantify immunoglobulins M, A and G against SARS-CoV-2 antigens

The paper develops and validates multiplex antibody assays to quantify IgM, IgA, and IgG against SARS-CoV-2 antigens, showing high specificity and sensitivity for detecting immune responses.

Ultrastructure of the axonal periodic scaffold reveals a braid-like organization of actin rings

The paper uses advanced microscopy techniques to reveal the ultrastructure of axonal actin rings, showing they are braided structures composed of intertwined actin filaments and spectrins.

Quantification of malaria antigens PfHRP2 and pLDH by quantitative suspension array technology in whole blood, dried blood spot and plasma

This paper develops and validates a quantitative suspension array technology to measure malaria antigens PfHRP2 and pLDH in various clinical samples, showing strong correlation with parasite density.

About samples, giving examples: Optimized Single Molecule Localization Microscopy

This paper provides detailed protocols for optimizing Single Molecule Localization Microscopy workflows, focusing on sample fixation, immunostaining, and data processing to enhance image quality and biological insights.

Automatic local resolution-based sharpening of cryo-EM maps.

This paper introduces a new automatic method for sharpening cryo-EM maps based on local resolution, improving map quality and interpretability.