P. Soultanas

Human HelQ and DNA polymerase δ interact to halt DNA synthesis and stimulate DNA single-strand annealing

This study shows HelQ interacts with DNA polymerase δ to stop DNA synthesis and enhance DNA single-strand annealing during repair.

Positive and negative control of helicase recruitment at a bacterial chromosome origin

This study identifies positive and negative mechanisms controlling helicase recruitment during bacterial chromosome replication initiation in Bacillus subtilis, with implications for drug development targeting DnaD.

Glycolytic pyruvate kinase moonlighting activities in DNA replication initiation and elongation

This study identifies PykA's moonlighting roles in DNA replication by showing its C-terminal domain interacts with replication enzymes and modulates fork speed and initiation.

Interaction of HelQ helicase with RPA modulates RPA-DNA binding and stimulates HelQ to unwind DNA through a protein roadblock.

This study identifies HelQ helicase's interaction with RPA, showing it enhances DNA unwinding through protein barriers but not abasic sites by destabilizing RPA-DNA binding.

DNA replication initiation in Bacillus subtilis; Structural and functional characterisation of the essential DnaA-DnaD interaction

This study characterizes the DnaA-DnaD interaction in Bacillus subtilis using NMR and single-molecule FRET, revealing structural details and functional roles in DNA replication initiation.