C. Cooper

Screening and characterization of 133 physiologically-relevant environmental chemicals for reproductive toxicity

The paper screens 133 chemicals for reproductive toxicity using C. elegans assays and compares results with ToxCast data, identifying 13 toxicants including QACs.

H-NS is a bacterial transposon capture protein

This study identifies H-NS as a transposon capture protein that directs transposition to specific chromosomal regions, affecting phenotypic diversity and gene function in bacteria.

Single-cell Spatial Metabolic and Immune Phenotyping of Head and Neck Cancer Tissues Identifies Tissue Signatures of Response and Resistance to Immunotherapy

This study uses single-cell spatial analysis to identify immune and metabolic tumor microenvironment signatures associated with response and resistance to immunotherapy in head and neck cancer.

Placental uptake and metabolism of 25(OH)Vitamin D determines its activity within the fetoplacental unit

This study shows the human placenta actively transports and metabolizes 25(OH)D3 into active vitamin D metabolites, influencing fetal development through placental transcriptome and proteome changes.

Novel murine models of post-implantation and midgestional malaria-induced preterm birth

This study introduces three novel murine models of malaria-induced preterm birth at different gestational stages and identifies distinct transcriptomic and parasitemia patterns associated with each model.

Therapeutic targeting of SETD2-deficient cancer cells with the small-molecule compound RITA

This paper identifies RITA as a compound that selectively kills SETD2-deficient cancer cells by inducing p53-mediated apoptosis and replication stress.

Endothelial cells elicit a pro-inflammatory response to SARS-COV-2 without productive viral infection

This study shows that endothelial cells can be infected by SARS-CoV-2 but do not produce infectious virus, instead triggering an inflammatory response through sensing adjacent infections.

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

An essential mycolate remodeling program for mycobacterial adaptation in host cells

The paper introduces Path-seq to study MTB transcription in host cells and identifies a mycolate remodeling program regulated by MadR during infection.

Semi-quantitative characterisation of mixed pollen samples using MinION sequencing and Reverse Metagenomics (RevMet)

This paper introduces RevMet, a pipeline for semi-quantitative characterization of mixed eukaryote samples using MinION sequencing and genome skims, demonstrating its effectiveness in identifying plant species in pollen samples.

Interaction of HelQ helicase with RPA modulates RPA-DNA binding and stimulates HelQ to unwind DNA through a protein roadblock.

This study identifies HelQ helicase's interaction with RPA, showing it enhances DNA unwinding through protein barriers but not abasic sites by destabilizing RPA-DNA binding.

Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer

This study identifies Hedgehog signaling to cancer-associated fibroblasts as a driver of cancer stem cell plasticity and chemoresistance in TNBC, showing that targeting this pathway with smoothened inhibitors improves survival in preclinical models and clinical trials.