Incorporation of the HIV-1 envelope glycoprotein into viral particles is regulated by the tubular recycling endosome in a cell type-specific manner
G. Lerner, L. Ding, K. Candor, P. Spearman
bioRxiv · Dec 17, 2023 · PreprintMicrobiology
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P. Spearman
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2023-2023 · peak 3/yrCo-Author Collaboration Network
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Tryptophan-based motifs in the LLP3 Region of the HIV-1 envelope glycoprotein cytoplasmic tail direct trafficking to the endosomal recycling compartment and mediate particle incorporation
G. Lerner, L. Ding, P. Spearman
This paper identifies two tryptophan-based motifs in the HIV-1 Env CT that mediate ERC localization and Env incorporation into viral particles.
bioRxiv · Apr 28, 2023Microbiology
KIF16B mediates anterograde transport and modulates lysosomal degradation of the HIV-1 envelope glycoprotein
N. Weaver, J. Hammonds, L. Ding, G. Lerner, K. Dienger-Stambaugh, P. Spearman
This study identifies KIF16B as a host motor protein that facilitates HIV-1 Env trafficking to the plasma membrane, prevents lysosomal degradation, and enhances viral particle incorporation and infectivity.
bioRxiv · Mar 1, 2023Microbiology