Claudin-4 modulates autophagy via SLC1A5/LAT1 as a tolerance mechanism for genomic instability in ovarian cancer.
F. R. Villagomez, J. Lang, P. Webb, M. Neville, E. R. Woodruff, B. G. Bitler
This study shows claudin-4 promotes genomic instability tolerance in ovarian cancer by linking cell junctions to autophagy via SLC1A5/LAT1, and targeting it enhances PARPi efficacy.
bioRxiv · Jan 18, 2024 · PreprintCancer Biology