J. Lang

Complexome profiling of the Chlamydomonas psb28 mutant reveals THYLAKOID ENRICHED FRACTION 5 as an early photosystem II assembly factor

The Chlamydomonas psb28 mutant shows severe PSII assembly defects, and complexome profiling identifies TEF5 as a novel PSII assembly factor involved in CP47 assembly.

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.

Antiviral Drug Discovery with an Optimized Biochemical Dengue Protease Assay: Improved Predictive Power for Antiviral Efficacy

This study improves the predictive power of a biochemical dengue protease assay for antiviral efficacy by optimizing conditions and evaluating phenylglycine-based inhibitors.

Continuous monitoring of glucose levels in vivo with a micro-organ based microfluidic biosensor

This study develops a microfluidic biosensor using pancreatic islets to monitor glucose levels in vivo, showing strong correlation between islet activity and glucose concentrations.

Extracellular electrophysiology on clonal human beta-cell spheroids

This study shows that clonal human beta-cell spheroids enhance electrical activity and hormone secretion compared to monolayers, suggesting they are better models for studying beta-cell function.

Ocean-scale variation in migration schedules of a long-distance migratory seabird is fully compensated upon return to the breeding site

The study tracks Arctic Skuas to show that migration timing variations are compensated upon return to breeding sites, with wintering area choices having minor effects on breeding timing.

Claudin-4 modulates autophagy via SLC1A5/LAT1 as a tolerance mechanism for genomic instability in ovarian cancer.

This study shows claudin-4 promotes genomic instability tolerance in ovarian cancer by linking cell junctions to autophagy via SLC1A5/LAT1, and targeting it enhances PARPi efficacy.

Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model.

This paper uses electrophysiological tools to functionally characterize iPSC-derived human β-like cells and assess the impact of a SLC30A8 variant on β-cell electrical coupling.

Screening of leaf extraction and storage conditions for eco-metabolomics studies

The paper screens extraction and storage methods for maize leaf metabolites to develop a reliable on-site protocol for tropical ecological studies.

Cell specialization and coordination in Arabidopsis leaves upon pathogenic attack revealed by scRNA-seq.

The paper uses scRNA-seq to identify cell-type-specific defense responses in Arabidopsis leaves infected with Pseudomonas syringae, revealing coordinated and divergent transcriptional programs.

Both transient and sustained MPK3/6 activities positively control expression of NLR genes in PTI and ETI.

Complexome profiling on the lpa2 mutant reveals insights into PSII biogenesis and new PSII associated proteins

The paper identifies LPA2 as a key factor in PSII biogenesis, showing that its absence leads to reduced PSII supercomplexes and increased instability of PSII monomers and assemblies.

An emerging role of Prevotella histicola on estrogen-deficiency induced bone loss through the gut microbiota-bone axis

This study identifies Prevotella histicola as a protective agent against estrogen-deficiency induced bone loss via the gut microbiota-bone axis in mice.

In vitro and in silico modeling of cellular and matrix-related changes during the early phase of osteoarthritis

This study combines in vitro and in silico models to simulate early osteoarthritis changes, showing inflammation-induced matrix degradation and partial reversibility.

Pelvic bone structures in free-ranging Eurasian lynx (Lynx lynx) from Switzerland: a radiological pelvimetry study

This study measures pelvic morphology in Eurasian lynx to assess congenital malformations and sexual dimorphism, finding no population differences but growth and sex-based variations.

No evidence for disruption of global patterns of nest predation in shorebirds

The paper challenges claims of climate change disrupting nest predation patterns in shorebirds, arguing that the original study's methodology is flawed and lacks statistical support.

Transfer of Xanthomonas campestris pv. arecae, and Xanthomonas campestris pv. musacearum to Xanthomonas vasicola (Vauterin) as Xanthomonas vasicola pv. arecae comb. nov., and Xanthomonas vasicola pv. musacearum comb. nov. and description of Xanthomonas vasicola pv. vasculorum pv. nov.

The paper transfers two Xanthomonas species to Xanthomonas vasicola and describes a new pathovar.

An assay for de novo kinetochore assembly reveals a key role for the CENP-T pathway in budding yeast

The paper develops a de novo kinetochore assembly assay in budding yeast to show that the CENP-T pathway becomes essential for viability and Ndc80c recruitment when the Mis12 pathway is impaired.