Single-molecule conformational dynamics of a transcription factor reveals a continuum of binding modes controlling association and dissociation
W. Chen, W. Liu, P. Wolynes, E. A. Komives
This study uses single-molecule FRET to show that NF-κB exhibits a continuum of binding modes that control its association and dissociation from DNA, with IκB modulating these dynamics.
bioRxiv · Mar 2, 2021Biophysics