The chemotherapeutic drug methotrexate selects for antibiotic resistance
J. S. Guthmundsdottir, E. G. A. Fredheim, C. I. M. Koumans, J. Hegstad, P.-C. Tang, D. I. Andersson, O. Samuelsen, P. J. Johnsen
This study shows methotrexate can select for antibiotic resistance genes in E. coli when linked to trimethoprim resistance, at sub-inhibitory concentrations.
bioRxiv · Nov 12, 2020Microbiology