D. I. Andersson

Suppression of the E. coli rnpA49 conditionally lethal phenotype via different compensatory mutations

The paper identifies temperature-resistant suppressor mutations in E. coli that compensate for the rnpA49 mutation in RNase P, revealing roles for Lon protease and RNase R in the mutant's degradation.

Theoretical Considerations and Empirical Predictions of the Pharmaco- and Population Dynamics of Heteroresistance

This paper develops two mathematical models of heteroresistance to explore how resistance ascends and reverts during antibiotic treatment, showing that current identification methods are insufficient.

The chemotherapeutic drug methotrexate selects for antibiotic resistance

This study shows methotrexate can select for antibiotic resistance genes in E. coli when linked to trimethoprim resistance, at sub-inhibitory concentrations.

Predicting trajectories and mechanisms of antibiotic resistance evolution

The paper develops a fitness model to predict antibiotic resistance evolution by linking metabolic effects to growth rates and resistance levels in E. coli.

Functional constraints on replacing an essential gene with its ancient and modern homologs

This study replaces the essential tufA gene in E. coli with extant and ancestral homologs, showing that functional transfer depends on the presence of tufB and evolutionary distance.