MicrobiologybioRxiv
The chemotherapeutic drug methotrexate selects for antibiotic resistance
J. S. Guthmundsdottir, E. G. A. Fredheim, C. I. M. Koumans…·P. J. Johnsen
This study shows methotrexate can select for antibiotic resistance genes in E. coli when linked to trimethoprim resistance, at sub-inhibitory concentrations.
DOI 10.1016/j.ebiom.2021.103742