P.-J. Wormald

A comparison between full-length 16S rRNA Oxford Nanopore sequencing and Illumina V3-V4 16S rRNA sequencing in head and neck cancer tissues

This study compares full-length 16S rRNA sequencing using Oxford Nanopore Technology (FL-ONT) with Illumina V3-V4 short-read sequencing in head and neck cancer tissues, finding FL-ONT provides better resolution at lower taxonomic levels.

Prophage acquisition by Staphylococcus aureus contributes to the expansion of Staphylococcal immune evasion

This study shows that acquisition of the {phi}Sa3int prophage by S. aureus alters its exoproteome, enhancing immune evasion and chronic infection potential.

Staphylococcus aureus biofilm secreted factors cause mucosal damage, mast cell infiltration and goblet cell hyperplasia in a rat rhinosinusitis model

This study shows that S. aureus biofilm secreted factors from CRS patients cause more severe mucosal inflammation in rats compared to controls.

The Intra-Host Evolutionary Landscape And Pathoadaptation Of Persistent Staphylococcus aureus In Chronic Rhinosinusitis

This study examines S. aureus persistence and pathoadaptation in CRS patients, finding 41% of isolates are persisters with increased biofilm biomass and plasmid copy numbers.

Microbiotyping the sinonasal microbiome

This study identifies three sinonasal microbiotypes using unsupervised machine learning on microbiome data and finds geographic differences in their distribution.

The international sinonasal microbiome study (ISMS): a multi-centre, multi-national collaboration characterising the microbial ecology of the sinonasal cavity

The paper characterizes the sinonasal microbiome globally using 16S rRNA sequencing, identifying a core microbiome and geographical variations in microbial diversity and composition.