S. Krishnan

A comparison between full-length 16S rRNA Oxford Nanopore sequencing and Illumina V3-V4 16S rRNA sequencing in head and neck cancer tissues

This study compares full-length 16S rRNA sequencing using Oxford Nanopore Technology (FL-ONT) with Illumina V3-V4 short-read sequencing in head and neck cancer tissues, finding FL-ONT provides better resolution at lower taxonomic levels.

Breast cancer cells can recognize and respond to different levels of progestins to achieve different phenotypic outputs

This study shows that breast cancer cells respond differently to low and high levels of progestins, with low levels promoting proliferation through specific molecular mechanisms.

Small extracellular vesicles promote stiffness-mediated metastasis

The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.

A marine cryptochrome with an inverse photo-oligomerization mechanism

This study identifies a marine cryptochrome, PdLCry, that undergoes inverse photo-oligomerization compared to plant CRYs, enabling light intensity discrimination for lunar cycle synchronization.

Long-Range Hopping Conductivity in Proteins

This paper explains how proteins without redox cofactors can conduct electricity efficiently by reducing the energy barrier for electron hopping through non-equilibrium states.

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma

Losartan prevents ICB-induced cerebral edema and improves survival in glioblastoma mice, with a predictive immune signature identified.

Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing

The paper shows that dissociation methods bias transcriptomes in sarcoma single-cell and single-nucleus RNA-seq, and demonstrates computational correction of these biases.

The Androgen Receptor: A Therapeutic Target in Desmoplastic Small Round Cell Sarcoma

The paper shows that DSRCT is driven by the androgen receptor and responds to androgen deprivation therapy.

Homeostatic control of c-di-AMP synthase (MsDisA) and hydrolase (MsPDE) from Mycobacterium smegmatis

This study characterizes the c-di-AMP synthase (MsDisA) and hydrolase (MsPDE) from M. smegmatis under different pH and osmolytic conditions, revealing their biochemical and structural regulation in response to environmental stress.

The Effect of COVID-19 on the Postdoctoral Experience: a comparison of pre-pandemic and pandemic surveys.

This study compares pre-pandemic and pandemic survey data of US postdocs, showing negative impacts on mental health, career progression, and job market perceptions, with international postdocs facing additional stressors.

Decoding assembly of alpha-helical transmembrane pores through intermediate states

This study decodes the multi-step structural assembly pathway of alpha-helical peptide pores using single-channel electrical recordings and mutant analysis.

Polymer-Conjugated Carbon Nanotubes for Biomolecule Loading

This study optimizes DNA loading on polymer-conjugated carbon nanotubes, assesses stability, and evaluates toxicity in plant systems.

Implications of central carbon metabolism in SARS-CoV-2 replication and disease severity

This study investigates how SARS-CoV-2 affects central carbon metabolism in host cells and links metabolic changes to disease severity.

Tropism of SARS-CoV-2 in commonly used laboratory cell lines and their proteomic landscape during infection

This study assesses SARS-CoV-2 tropism and proteomic changes in human cell lines, finding cell-type-specific susceptibility and interferon signaling dysregulation.

N-glycosylation network construction and analysis to modify glycans on the spike S glycoprotein of SARS-CoV-2.

The paper constructs and analyzes an N-glycosylation network of SARS-CoV-2 spike protein to identify key enzymes and their impact on glycan profiles.

Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells

The paper identifies dysregulation in mTOR/HIF-1 signaling in SARS-CoV-2 infected cells through proteo-transcriptomics analysis.

Multispectral Imaging Differentiates Unique Macrophage Profiles in Patients with Distinct Chronic Liver Diseases

This study uses multispectral imaging to analyze macrophage profiles in liver biopsies from patients with chronic liver diseases, revealing distinct macrophage phenotypes associated with different fibrosis stages and disease types.

Cryo-EM Structure of OSCA1.2 from Oryza sativa: Mechanical basis of hyperosmolality-gating in Plants

The paper reports the cryo-EM structure of OsOSCA1.2 from rice, revealing its mechanism for sensing hyperosmolality and mediating ion permeability through structural dynamics.