RNA structure through multidimensional chemical mapping
This paper introduces multidimensional chemical mapping methods to determine RNA structures and shows they accurately resolve secondary and tertiary structures of various RNA molecules.
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3 papers
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This paper introduces multidimensional chemical mapping methods to determine RNA structures and shows they accurately resolve secondary and tertiary structures of various RNA molecules.
Clarence Cheng, Fang-Chieh Chou, Wipapat Kladwang…·Rhiju Das
MOHCA-seq provides nucleotide-resolution RNA 3D structure models from single experiments, revealing new insights into ligand-induced conformational changes in riboswitches.
Siqi Tian, Pablo Cordero, Wipapat Kladwang, Rhiju Das
The paper corrects an erroneous SHAPE-directed RNA structure inference using a mutate-map-rescue approach and identifies a functional conformational state in 16S rRNA.