Cysteines are critical determinants of spontaneous and seeded tau aggregation in cells
Łukasz A. Joachimiak, Parvathy Jayan, Simran Rastogi, Vaibhav Bommareddy, Chad Dashnaw, Jaime Vaquer‐Alicea, Binh An Nguyen, Lorena Saelices, Sarah H. Shahmoradian, Charles L. White, Marc I. Diamond
This study identifies cysteine residues as critical for tau aggregation and propagation in cells, both spontaneously and when seeded.
bioRxiv · Mar 16, 2026 · PreprintBiophysics