Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model
Antara T. Rao, Nuo Chen, Min Joo Kim, Jessica R. Blumenfeld, Oscar Yip, Yanxia Hao, Zherui Liang, Maxine R. Nelson, Nicole Koutsodendris, Brian P. Grone, Leo Ding, Seo Yeon Yoon, Patrick Arriola, Yadong Huang
The paper investigates the role of microglia in APOE4-driven Alzheimer's pathology using a chimeric model, finding that microglia are required for APOE4-induced pathologies.
bioRxiv · Nov 10, 2023 · PreprintNeuroscience