Author

Paul Chang

Koch Institute for Integrative Cancer Research At MIT

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrew MehleiD· 1 shared Anthony K. L. LeungiD· 1 shared Che-Yuan Chang· 1 shared Elizabeth M Feltman· 1 shared Gloria P. LarsoniD· 1 shared Isabel R. UribeiD· 1 shared Jens H. KuhniD· 1 shared Kaitlin A. Davis· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Andrew MehleORCID

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1 paper

Recent·Most cited

Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection

Zhenyu Zhang, Isabel R. Uribe, Kaitlin A. Davis, Robert Lyle McPherson, Gloria P. Larson, Mohsen Badiee, Vy Tran, Mitchell P. Ledwith, Elizabeth M Feltman, Shuǐqìng Yú, Yíngyún Caì, Che-Yuan Chang, Xingyi Yang, Zhuo Ma, Paul Chang, , Andrew Mehle

The paper shows influenza A virus infection increases global ADP-ribosylation, which inhibits viral replication, and identifies PARP1 as the main enzyme involved, with NS1 counteracting this effect.

Nature Communications · Dec 17, 2025Peer-reviewedMicrobiology