Author

PCAWG network

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Amit Deshwar· 1 shared C. M. Lalansingh· 1 shared Caitlin F Harrigan· 1 shared D. H. Park· 1 shared E. Drysdale· 1 shared F. Fan· 1 shared F. Yousif· 1 shared Jeff Wintersinger· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Amit Deshwar

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2 papers

Recent·Most cited

TrackSig: reconstructing evolutionary trajectories of mutations in cancer

Yulia Rubanova, Ruian Shi, Caitlin F Harrigan, Roujia Li, Jeff Wintersinger, Nil Sahin, Amit Deshwar, Quaid Morris, PCAWG Evolution and Heterogeneity Working Group, PCAWG network

TrackSig estimates mutation evolutionary trajectories from bulk tumor sequencing data, showing improved accuracy in detecting subclonal populations and signature activity changes compared to baseline methods.

bioRxiv · Sep 30, 2019 · PreprintBioinformatics

The Origins and Consequences of Localized and Global Somatic Hypermutation

F. Yousif, S. Prokopec, R. X. Sun, F. Fan, C. M. Lalansingh, E. Drysdale, D. H. Park, L. Szyca, PCAWG Network, P. C. Boutros

This study identifies genes driving localized and global hypermutation in tumors and finds that kataegis (localized mutation rainstorms) are associated with specific genetic alterations and patient outcomes.

bioRxiv · Jun 29, 2018 · PreprintCancer Biology