F. Fan

Role of Dusp5 KO on Vascular Properties of Middle Cerebral Artery in Rats

This study examines the structural and mechanical properties of the middle cerebral artery in Dusp5 KO rats, finding limited structural changes but enhanced myogenic tone, suggesting Dusp5's role in hemodynamics and cognition is enzyme-driven.

A COVID-19 DNA Vaccine Candidate Elicits Broadly Neutralizing Antibodies Against Multiple SARS-CoV-2 Variants Including the Currently Circulating Omicron BF.5, BF.7, BQ.1 and XBB

Potent Immunogenicity and Broad-Spectrum Protection Potential of Microneedle Array Patch-Based COVID-19 DNA Vaccine Candidates Encoding Dimeric RBD Chimera of SARS-CoV and SARS-CoV-2 Variants

This study develops DNA vaccines encoding chimeric RBDs of SARS-CoV and SARS-CoV-2 variants, showing potent immunogenicity and broad neutralization against multiple variants.

Temporal and Spatial Resolution of a Protein Quake that Activates Hydrogen Tunneling in Soybean Lipoxygenase

This study investigates hydrogen tunneling in soybean lipoxygenase using X-ray and deuterium exchange experiments, revealing a protein quake mechanism linked to catalytic activation.

Cryo-electron microscopy revealed TACAN is extensively and specifically associated with membrane lipids

The paper reveals TACAN is a homodimer with lipid-associated domains and suggests membrane lipids coordinate with the protein to sense mechanical signals.

Liver Endothelium Promotes HER3-mediated Cell Survival in KRAS Wild-type and Mutant Colorectal Cancer Cells

The paper shows liver endothelial cells promote HER3-mediated survival in KRAS wild-type and mutant colorectal cancer cells through secreted factors, suggesting HER3 as a therapeutic target regardless of KRAS mutation status.

High-resolution single-molecule long-fragment rRNA gene amplicon sequencing for uncultured bacterial and fungal communities

This study develops a method to sequence nearly full-length rRNA genes from environmental samples, achieving high accuracy and coverage in microbial community analysis.

Identifying Dihydropyrimidine Dehydrogenase as a Novel Regulator of Hepatic Steatosis

This study identifies DPYD as a regulator of hepatic steatosis through in vitro experiments showing its inhibition reduces lipid accumulation and its gain-of-function mutation increases lipid burden.

20-HETE-promoted cerebral blow flow autoregulation is associated with enhanced α-smooth muscle actin positive cerebrovascular pericyte contractility

This study shows that 20-HETE enhances pericyte contractility and cerebral blood flow autoregulation in rats by modulating vascular smooth muscle cell function.

A Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene Silencing

The paper develops a proteomics platform to identify off-target proteins affected by PROTAC and RNAi therapies, using a selected off-target proteome and LC-MS/MS quantification.

CD44 regulates blood-brain barrier integrity in response to fluid shear stress.

This study identifies CD44 as a key regulator of blood-brain barrier integrity under fluid shear stress, showing its role in mechanotransduction and barrier formation.

High innate preference for black substrate in the chive gnat, Bradysia odoriphaga (Diptera: Sciaridae)

This study shows that chive gnat adults prefer black substrates regardless of color hues, brightness, or ambient light conditions.

The Utilization of Pharmacophore-based 3D QSAR Modeling and Virtual Screening in Safety Profiling: a Case Study to Identify Antagonistic Activities against Adenosince Receptor, A2aR, using 1,897 known drugs

The Origins and Consequences of Localized and Global Somatic Hypermutation

This study identifies genes driving localized and global hypermutation in tumors and finds that kataegis (localized mutation rainstorms) are associated with specific genetic alterations and patient outcomes.