Author

Peng Lyu

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

C. GuoiD· 4 shared Gaurav AgarwaliD· 4 shared Mateusz AntoszewskiiD· 4 shared Tianyi YeiD· 4 shared Vijay G. SankaraniD· 4 shared Alexis CaulieriD· 2 shared Andrew LeeiD· 2 shared Lara WahlsteriD· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetics

C. GuoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Durable and reversible epigenetic programming of human hematopoietic stem cells as a platform for modulation of platelet function

Tianyi Ye, Wanying Xu, María N. Barrachina, Peng Lyu, Mateusz Antoszewski, Lucrezia della Volpe, C. Guo, Andrew Lee, Emily Villalpando, Issac A. Johnson, Madelaine Skolastika Theardy, Spencer D. Shelton, Lara Wahlster, Alexis Caulier, Luana Messa, , Vijay G. Sankaran

This study uses DNA methylation-based epigenome editing to durably and reversibly silence genes in human hematopoietic stem cells, demonstrating its application in modulating platelet function.

bioRxiv · Oct 8, 2026 · PreprintGenomics

Human genetics implicates a BACH2-NRF2 axis in fetal hemoglobin activation

C. Guo, Uma P. Arora, Xiaoheng Cheng, Wanying Xu, Liam D. Cato, Rick Li, Henry Y. Lu, Andrew Lee, Fulong Yu, Gaurav Agarwal, Peng Lyu, Tianyi Ye, Mateusz Antoszewski, Mariel Wissmann, Baraka Stewart Mkumbe, , Vijay G. Sankaran

This study identifies a BACH2-NRF2 axis regulating fetal hemoglobin activation through genetic and functional analyses in a large multi-ancestry cohort.

Nature · Sep 30, 2026Peer-reviewedGenetic & Genomic Medicine

Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells

Peng Lyu, Gaurav Agarwal, C. Guo, Adam Sychla, Wallace Bourgeois, Tianyi Ye, Chen Weng, Mateusz Antoszewski, Samantha Joubran, Alexis Caulier, Michael Poeschla, Scott A. Armstrong, Silvi Rouskin, Vijay G. Sankaran

The paper identifies a genetic variant associated with reduced blood counts and cancer protection, showing it disrupts a lncRNA that regulates HOXA gene expression in hematopoietic stem cells.

Cell · May 1, 2026Peer-reviewedGenetics

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation

Gaurav Agarwal, Mateusz Antoszewski, Xuejun Xie, Yash Pershad, Uma P. Arora, Chi-Lam Poon, Peng Lyu, Andrew J. Lee, C. Guo, Tianyi Ye, Laila Barakat Norford, Anna‐Lena Neehus, Lucrezia della Volpe, Lara Wahlster, Diyanath Ranasinghe, , Vijay G. Sankaran

The paper identifies a genetic variant that protects against clonal hematopoiesis by regulating RNA-binding protein MSI2 in hematopoietic stem cells.

Science · Jan 1, 2026Peer-reviewedGenetics