Author
Boston Children's HospitalORCID 0000-0002-9099-4728Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Peng Lyu, Gaurav Agarwal, C. Guo…·Vijay G. Sankaran
The paper identifies a genetic variant associated with reduced blood counts and cancer protection, showing it disrupts a lncRNA that regulates HOXA gene expression in hematopoietic stem cells.
James B. Shaum, Miquel Muñoz i Ordoño, Erica A. Steen…·Michael A. Erb
This study uses high-throughput chemistry to discover chemical inducers of proximity by modifying pre-existing ligands and screening for degrader activity.
Anthony M. Doherty, Eimear Lagan, Richard J. R. Elliott…·Gerard L. Brien
This study shows SS18-SSX sustains oncogenic transcription without needing SWI/SNF activity, identifies P300 as a critical co-factor, and demonstrates targeting P300 or SWI/SNF as therapeutic strategies.
Shellaina J.V. Gordon, Florian Perner, Laura MacPherson…·Mark A. Dawson
The paper shows that inhibiting KAT6/KAT7 enhances Menin inhibitor efficacy and overcomes resistance in MLL-FP leukemia.
Nicole Lynn Michmerhuizen, Emily Heikamp, Ilaria Iacobucci…·Charles Grenfell Mullighan
This study identifies MOZ and HBO1 as molecular dependencies in NUP98-rearranged AML, showing their inhibition reduces leukemic burden and synergizes with Menin inhibitors.