PD-1 remodels SHP2 dynamics and drives the non-catalytic inhibition of T cell activation
Panyu Fei, Peng Jiao, Jie Gao, Hui Chen, Yu Zhang, Lu Chen, Peng Wu, Lina Chen, Salvatore Valvo, Michael Loran Dustin, Jizhong Lou, Chun Zhou, Wei Chen
This study reveals that PD-1 remodels SHP2 dynamics to inhibit T cell activation through a non-catalytic mechanism, independent of its phosphatase activity.
bioRxiv · May 22, 2026 · PreprintImmunology