Yu Zhou

Mechanistic insights into coronavirus inhibition by a distinct base-modified adenosine analog targeting the viral polymerase

This paper investigates the mechanism of 6-ethyl-modified 7-deazaadenosine (EDA) as a coronavirus inhibitor, showing it stalls viral polymerase without causing mutagenesis.

Reticulate Evolution and Plastome Restructuring Shape Asian Passiflora Diversification

This study investigates the evolutionary relationships and plastome evolution of Asian Passiflora species, revealing reticulate evolution, incomplete lineage sorting, and population differentiation.

CycDelta: Multimodal Residue-Graph Learning of Permeability Changes in Cyclic Peptides

CycDelta is a multimodal residue-graph model for predicting permeability changes in cyclic peptides by comparing within-source permeability differences, outperforming baselines on out-of-distribution and zero-shot tasks.

Reduced recombination relative to mutation characterizes dominant circulating clones of Mycobacterium abscessus

The paper analyzes genomic diversity in Mycobacterium abscessus, finding that dominant clones show increased accessory-gene gains and reduced recombination relative to mutation after establishment.

Proteome profiling of plant Cajal bodies uncovers kingdom-specific components

The paper profiles the proteome of plant Cajal bodies, revealing a distinct kingdom-specific composition compared to animal CBs.

A colorectal cancer organoid-CAF co-culture chip for drug screening and personalized therapy

This paper develops a co-culture chip to model colorectal cancer TME with CAFs, showing improved drug response prediction and tumor recurrence compared to organoid-only models.

A hybrid framework integrating structural machine learning and 3D liver-on-chip assay for drug-induced liver injury prediction

Oakuloid combines a structural machine learning model with a 3D liver-on-chip assay to predict drug-induced liver injury, achieving high AUROC on external benchmarks and offering orthogonal confirmation signals.

Strigolactone signaling regulates corm development through SPL15-mediated hormonal crosstalk in banana

This study investigates how strigolactone signaling regulates corm development in banana through SPL15-mediated hormonal crosstalk, identifying key gene expression changes and pathway interactions.

Engineering auxin degradation into root-associated bacteria promotes plant growth

The paper engineers auxin-degrading bacteria to alleviate root growth inhibition and improve plant growth.

The structural basis of translational control by eIF2 phosphorylation

This study determines the structures of phosphorylated and unphosphorylated eIF2 bound to eIF2B, revealing how eIF2 phosphorylation modulates translational control through altered binding affinity.