Lu Chen

Adaptive introgression in Tibetans spans focal and distributed architectures

This study identifies Neanderthal-derived adaptive variation in Tibetans, showing functional convergence in immune and metabolic pathways, beyond the well-known EPAS1 locus.

Primordial cardiomyocytes orchestrate myocardial morphogenesis and vascularization but are dispensable for regeneration

The paper identifies a unique cardiomyocyte subpopulation in zebrafish hearts that is essential for development but not regeneration.

Intravital imaging of age-related conjunctival lymphatic changes on the ocular surface

This study uses intravital imaging to examine age-related changes in conjunctival lymphatics, finding reduced vascular branching and functional impairments in aged mice.

The engulfment receptor CED-1/MEGF10 activates the GPCR LAT-1/ADGRL3 for apoptotic cell degradation

This study identifies a conserved signaling pathway involving CED-1/MEGF10 and LAT-1/ADGRL3 that regulates apoptotic cell clearance through a transcriptional cascade.

PD-1 remodels SHP2 dynamics and drives the non-catalytic inhibition of T cell activation

This study reveals that PD-1 remodels SHP2 dynamics to inhibit T cell activation through a non-catalytic mechanism, independent of its phosphatase activity.

Molecular Glue-Induced Homodimerization Drives Targeted CRBN Autodegradation

This paper introduces LJY-3-60, a molecular glue that induces CRBN homodimerization and autodegradation, providing a tool for controlled protein degradation.

Soleus H-Reflex Up-Conditioning during Sciatic Nerve Regeneration in Rats Improves Recovery of Locomotion

This study shows that H-reflex up-conditioning during sciatic nerve regeneration in rats improves H-reflex recovery and locomotor symmetry, while down-conditioning has no negative effect.

Hypothalamic CRH Neurons Modulate Sevoflurane Anesthesia and The Post-anesthesia Stress Responses

This study identifies PVHCRH neurons as regulators of sevoflurane anesthesia and post-anesthesia stress responses through chemogenetic and optogenetic manipulations.